Adenosine Triphosphate-Sensitive Potassium Currents in Heart Disease and Cardioprotection
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چکیده
منابع مشابه
Estrogen and adenosine triphosphate-sensitive potassium channels.
Potassium Channels To the Editor: We read with interest the publication by Lee et al1 describing the potential mechanisms and effects of intracoronary conjugated estrogens on coronary vasomotion and myocardial ischemia in patients undergoing percutaneous coronary angioplasty. We were surprised at the very high bolus dose of intracoronary Premarin (Wyeth-Ayerst) given—5 mg into the left coronary...
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BACKGROUND ATP-sensitive potassium (K(ATP)) channel openers provide cardioprotection in multiple models. Ion flux at an unidentified mitochondrial K(ATP) channel has been proposed as the mechanism. The renal outer medullary kidney potassium channel subunit, potassium inward rectifying (Kir)1.1, has been implicated as a mitochondrial channel pore-forming subunit. We hypothesized that subunit Kir...
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NICHOLS, C. G., AND W. J. LEDERER. Adenosine triphosphate-sensitive potassium channels in the cardiovascular system. Am. J. Physiol. 261 (Heart Circ. Physiol. 30): H1675-H1686, 1991.-ATP is normally available in cells at millimolar concentrations and is “buffered” by intracellular pools of other high-energy phosphates, such as creatine phosphate. Thus intracellular [ATP] ([ATPI;) may seem an un...
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Cardiomyopathies have been indicated to be one of the leading causes of heart failure. Though it was indicated that genetic defects, viral infection and trace element deficiency were among the causes of cardiomyopathy, the etiology has remained to be fully elucidated. Cardiomyocytes require large amounts of energy to maintain their normal biological functions. Adenosine triphosphate-sensitive p...
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KATP channels are a newly defined class of potassium channels based on the physical association of an ABC protein, the sulfonylurea receptor, and a K+ inward rectifier subunit. The beta-cell KATP channel is composed of SUR1, the high-affinity sulfonylurea receptor with multiple TMDs and two NBFs, and KIR6.2, a weak inward rectifier, in a 1:1 stoichiometry. The pore of the channel is formed by K...
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ژورنال
عنوان ژورنال: Cardiac Electrophysiology Clinics
سال: 2016
ISSN: 1877-9182
DOI: 10.1016/j.ccep.2016.01.005